Áóäóùåå áûñòðåå, ÷åì âû äóìàåòå. Êàê òåõíîëîãèè ìåíÿþò áèçíåñ, ïðîìûøëåííîñòü è íàøó æèçíü Êîòëåð Ñòèâåí

82. Brown M. How Microsoft Is Shaking Up Fashion with Mixed Reality, AI, and IoT // Windows Central, June 9, 2018 // windowscentral.com/­microsoft-fashion-mixed-reality-ai-iot.

Ãëàâà 6. Áóäóùåå ðåêëàìû

1. Avent R. The Wealth of Humans: Work, Power, and Status in the Twenty-First Century. St. Martins, 2016. P. 3.

5. Lynley M. Google Joins the Race to $1 Trillion // TechCrunch, July 23, 2018 // techcrunch.com/­2018/­07/­23/­google-joins-the-race-to-1-trillion/­.

6. Egan M. Facebook and Amazon Hit $500 Billion Milestone // CNN, July 27, 2017 // money.cnn.com/­2017/­07/­27/­investing/­facebook-amazon-500-billion-bezos-zuckerberg/­index.html.

7. Constine J. Snapchat Lets You Take a Photo of an Object to Buy It on Amazon // TechCrunch, September 24, 2018 // techcrunch.com/­2018/­09/­24/­snapchat-amazon-visual-search/­.

10. Pardes A. Ikea’s New App Flaunts What You’ll Love Most About AR // Wired, September 20, 2017 // wired.com/­story/­ikea-place-ar-kit-augmented-reality/­.

11. Wurmser Y. Visual Search 2018: New Tools from Pinterest, eBay, Google and Amazon Increase Accuracy, Utility // eMarketer, September 26, 2018 // emarketer.com/­content/­visual-search-2018.

12. Partner Content. How Lyrebird Uses AI to Find Its (Artificial) Voice // Wired // wired.com/­brandlab/­2018/­10/­lyrebird-uses-ai-find-artificial-voice/­. Ñì. òàêæå: lyrebird.ai.

13. Allen G. AI Will Make Forging Anything Entirely Too Easy // Wired, July 1, 2017 // wired.com/­story/­ai-will-make-forging-anything-entirely-too-easy/­.

14. Dormehl L. Baidu’s New A.I. Can Mimic Your Voice After Listening to It for Just One Minute // Digital Trends, February 28, 2018 // digitaltrends.com/­cool-tech/­baidu-ai-emulate-your-voice/­.

15. Mack D. This PSA About Fake News from Barack Obama Is Not What It Appears // BuzzFeed News, April 17, 2018 // buzzfeednews.com/­article/­davidmack/­obama-fake-news-jordan-peele-psa-video-buzzfeed.

16. Technology. The Real Danger of DeepFake Videos Is That We May Question Everything // NewScientist, August 29, 2018 // newscientist.com/­article/­mg23931933-200-the-real-danger-of-deepfake-videos-is-that-we-may-question-everything/­. Ñì. òàêæå: Swartz O. You Thought Fake News Was Bad? Deep Fakes Are Where Truth Goes to Die // Guardian, November 12, 2018 // theguardian.com/­technology/­2018/­nov/­12/­deep-fakes-fake-news-truth.

17. Ñì. îðèãèíàë ñòàòüè ñïåöèàëèñòîâ èç Óíèâåðñèòåòà Êàðíåãè — Ìåëëîíà: cmu.edu/­news/­stories/­archives/­2018/­september/­deep-fakes-video-content.html.

18. Afshar V. How AI-Powered Commerce Will Change Shopping // ZDNet, December 21, 2018 // zdnet.com/­article/­how-ai-powered-commerce-will-change-shopping/­.

Ãëàâà 7. Áóäóùåå ðàçâëå÷åíèé

1. Hastings R. How I Did It: Reed Hastings, Netflix // Inc. Magazine, December 1, 2005 // inc.com/­magazine/­20051201/­qa-hastings.html.

2. Helft M. Netflix to Deliver Movies to the PC // New York Times, January 16, 2007 // nytimes.com/­2007/­01/­16/­technology/­16netflix.html.

3. Iqbal M. Netflix Revenue and Usage Statistics (2018) // Business of Apps, February 27, 2019 // businessofapps.com/­data/­netflix-statistics/­.

4. Iqbal M. Netflix Revenue and Usage Statistics (2018) // Business of Apps, February 27, 2019 // businessofapps.com/­data/­netflix-statistics/­.

5. Ha A. Netflix Added 9.6M Subscribers in Q1, with Revenue of $4.5B // TechCrunch, April 16, 2019 // techcrunch.com/­2019/­04/­16/­netflix-q1-earnings/­.

6. Netflix Market Cap 2006-2019 | NFLX // Macrotrends.com // macrotrends.net/­stocks/­charts/­NFLX/­netflix/­market-cap.

7. Alsin A. The Future of Media: Disruptions, Revolutions and the Quest for Distribution // Forbes, July 19, 2018 // forbes.com/­sites/­aalsin/­2018/­07/­19/­the-future-of-media-disruptions-revolutions-and-the-quest-for-distribution/­#5a2­ca5­2d6­0b9.

8. Netflix Is Moving Television Beyond Time-Slots and National Markets // Economist, June 30, 2018 // economist.com/­briefing/­2018/­06/­30/­netflix-is-moving-television-beyond-time-slots-and-national-markets.

9. Spangler T. Netflix Eyeing Total of About 700 Original Series in 2018 // Variety, February 27, 2018.

10. Graser M. Epic Fail: How Blockbuster Could Have Owned Netflix // Variety, November 12, 2013 // variety.com/­2013/­biz/­news/­epic-fail-how-blockbuster-could-have-owned-netflix-1200823443/­.

11. Mickle T. Apple Readies $1 Billion War Chest for Hollywood Programming // Wall Street Journal, August 16, 2017 // wsj.com/­articles/­apple-readies-1-billion-war-chest-for-hollywood-programming-1502874004.

12. Levy A. Here’s Exactly How Much Amazon Is Spending on Video and Music Content // Motley Fool, April 30, 2019 // fool.com/­investing/­2019/­04/­30/­heres-how-much-amazon-is-spending-on-video-music.aspx.

13. Îáùåìèðîâûå äîõîäû ÒÂ: Global TV Revenues Grow to $265 Billion // Broadband TV News, October 22, 2018 // broadbandtvnews.com/­2018/­10/­22/­global-tv-revenues-grow-to-265-billion/­. Îáùåìèðîâûå êàññîâûå ñáîðû: McClintock P. Global Box Office Revenue Hits Record $41B in 2018, Fueled by Diverse U.S. Audiences // Hollywood Reporter, March 21, 2019 // hollywoodreporter.com/­news/­global-box-office-revenue-hits-record-41b-2018-fueled-by-diverse-us-audiences-1196010.

14. Me at the Zoo (video), April 23, 2005 // youtube.com/­watch?v=jNQXAC9IVRw.

15. Ronaldinho Nike Ad (video), August 2, 2006 // youtube.com/­watch?v=i_­JS1YG8H2c.

16. Helft M. Venture Firm Shares a YouTube Jackpot // New York Times, October 10, 2006 // nytimes.com/­2006/­10/­10/­technology/­10payday.html.

17. Helft M. Venture Firm Shares a YouTube Jackpot // New York Times, October 10, 2006 // nytimes.com/­2006/­10/­10/­technology/­10payday.html.

18. Over One Billion Users. Ñì.: youtube.com/­about/­press/­.

19. Binging with Babish (video). Ñì.: youtube.com/­user/­bgfilms.

20. Cooking with Dog (video). Ñì.: youtube.com/­user/­cookingwithdog.

21. My Drunk Kitchen (video). Ñì.: youtube.com/­user/­MyHarto.

22. Robehmed N. Highest-Paid YouTube Stars 2018: Markiplier, Jake Paul, Pewdiepie and More // Forbes, December 3, 2018 // forbes.com/­sites/­natalierobehmed/­2018/­12/­03/­highest-paid-youtube-stars-2018-markiplier-jake-paul-pewdiepie-and-more/­#22c­282­8e9­09a.

23. Bambuser. Ñì.: bambuser.com.

24. Sunspring (video). Ñì.: youtube.com/­watch?v=LY7x2Ihqjmc.

25. BM Creates First Movie Trailer by AI [HD] | 20th Century FOX, August 31, 2016 // youtube.com/­watch?v=gJEzuYynaiw.

26. Guzdial M. Crowdsourcing Open Interactive Narrative // cc.gatech.edu/­~riedl/­pubs/­guzdial-fdg15.pdf. Ñì. òàêæå: Artificial Intelligence System for Crowdsourcing Interactive Fiction (video), September 1, 2016 // youtube.com/­watch?time_­continue=1&v=znqw17aOrCs.

27. Category: Video Games with User-Generated Gameplay Content // Wikipedia // en.wikipedia.org/­wiki/­Category:Video_­games_­with_­user-generated_­gameplay_­content.

29. Chan C. Everybody Dance Now // Arvix.org, August 22, 2018 // arxiv.org/­pdf/­1808.07371v1.pdf.

30. Áåñåäà àâòîðà ñ Òîíè Ðîááèíñîì, 2018.

31. AI Personas Based on Real People // rivaltheory.com.

32. Æþëü Óðáàõ, áåñåäà ñ àâòîðîì, 2018. Ñì. òàêæå: Georgiadis F. The Future Is Now: ‘Now We Can Effortlessly Interact with Digital Holographic Objects That Naturally Blend into Everyday Life’ with OTOY CEO Jules Urbach & Fotis Georgiadis // Thrive Global, January 16, 2019 // thriveglobal.com/­stories/­the-future-is-now-now-we-can-effortlessly-interact-with-digital-holographic-objects-that-naturally-blend-into-everyday-life-with-otoy-ceo-jules-urbach-fotis-georgiadis/­.

33. Otoy. Ñì.: home.otoy.com.

35. High Fidelity Raises $35m to Bring Virtual Reality to 1 Billion People // High Fidelity, June 28, 2018 // prnewswire.com/­news-releases/­high-fidelity-raises-35m-to-bring-virtual-reality-to-1-billion-people-300673807.html.

36. NeoSensory // neosensory.com/­?v=7516fd43adaa. Ñì. òàêæå: Eagleman D. Can We Create New Senses for Humans? // TED Talk // ted.com/­talks/­david_­eagleman_­can_­we_­create_­new_­senses_­for_­humans.

37. Dreamscape. Ñì.: dreamscapeimmersive.com/­. Ñì. òàêæå: Bishop B. Dreamscape Immersive Wants to Bring Location-Based VR to the Masses, Starting with a Shopping Mall // Verge, January 15, 2019 // theverge.com/­2019/­1/­15/­18156854/­dreamscape-immersive-virtual-reality-los-angeles-walter-parkes-bruce-vaughn (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñ­òîðîì).

38. Ramirez G. A. Color Analysis of Facial Skin: Detection of Emotional State // University of Texas // cs.utep.edu/­ofuentes/­papers/­emotionSkin_­final.pdf.

39. Affectiva // affectiva.com/­. Ñì. òàêæå: Marwan S. Rana El Kaliouby CEO of Affectiva Is Training Robots to Read Feelings // Forbes, November 29, 2018 // forbes.com/­sites/­samarmarwan/­2018/­11/­29/­affectiva-emotion-ai-ceo-rana-el-kaliouby/­#7d5­f8c­5c1­572.

40. Finding the Essence of Fear in Nevermind // July 21, 2016 // blog.affectiva.com/­finding-the-essence-of-fear-in-nevermind.

41. Foster T. Ready or Not, Companies Will Soon Be Tracking Your Emotions // Inc. Magazine, July 2016 // inc.com/­magazine/­201607/­tom-foster/­lightwave-monitor-customer-emotions.html.

42. Ubumo. Ñì.: ubimo.com.

43. Cluep. Ñì.: cluep.com.

44. Lopez R. ‘Choose Your Own Adventure’ Interactive Movie in the Works at Fox // Variety, April 26, 2018 // variety.com/­2018/­film/­news/­choose-your-own-adventure-interactive-1202788741/­.

45. Spiegel J. Does a ‘Choose Your Own Adventure’ Movie Sound Appealing? // Hollywood Reporter // hollywoodreporter.com/­heat-vision/­choose-your-own-adventure-movie-does-it-sound-appealing-1106999.

46. Ðîíè Àáîâèö, áåñåäà ñ àâòîðîì, 2018 ã. Ñì. òàêæå: Magic Leap // magicleap.com/­; Yang P. The Untold Story of Magic Leap, the World’s Most Secretive Startup // Wired // wired.com/­2016/­04/­magic-leap-vr/­.

47. OLED Lighting Products: Capabilities, Challenges, Potential // U.S. Department of Energy, May 2016 // energy.gov/­sites/­prod/­files/­2016/­08/­f33/­ssl_­oled-products_­2016.pdf.

48. Bendy Smartphone Made of Graphene Displayed at China Tech Fair (video), April 27, 2016 // youtube.com/­watch?v=ZwuQXfHXsa4. Ñì. òàêæå: Porter J. Nubia’s New Wearable Puts a 4-Inch Flexible Smartphone on Your Wrist // Verge // theverge.com/­circuitbreaker/­2019/­2/­25/­18240370/­nubia-alpha-release-date-price-features-wearable-smartwatch-flexible-display-mwc-2019.

49. For AR/VR 2.0 to Live, AR/VR 1.0 Must Die // Digi-Capital, January 15, 2019 // digi-capital.com/­news/­2019/­01/­for-ar-vr-2-0-to-live-ar-vr-1-0-must-die/­.

50. Phelan D. Apple CEO Tim Cook: As Brexit Hangs over UK, ‘Times Are Not Really Awful, There’s Some Great Things Happening’ // Independent // independent.co.uk/­life-style/­gadgets-and-tech/­features/­apple-tim-cook-boss-brexit-uk-theresa-may-number-10-interview-ustwo-a7574086.html.

51. Munsi L. Pokemon GO Surpasses the 1 Billion Downloads Milestone // Nintendo Wire, July 31, 2019 // nintendowire.com/­news/­2019/­07/­31/­pokemon-go-surpasses-the-1-billion-downloads-milestone/­.

52. Iqbal M. Pokemon GO Revenue and Usage Statistics (2019) // Business of Apps, May 10, 2019 // businessofapps.com/­data/­pokemon-go-statistics/­.

53. Ñì.: mojo.vision. Ñì. òàêæå: Takahashi D. Mojo Vision Reveals the World’s Smallest and Densest Micro Display // Venture Beat // venturebeat.com/2019/05/30/mojo-vision-reveals-the-worlds-smallest-and-densest-micro-display/ (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì).

54. Minkyu A. A Review of Brain-Computer Interface Games and an Opinion Survey from Researchers, Developers and Users // Sensors, August 2014. Pp. 14601–14633, doi: 10.3390/­s140814601. Ñì.: ncbi.nlm.nih.gov/­pmc/­articles/­PMC4178978/­.

55. Linxing J. P., BrainNet: A Multi-Person Brain-to-Brain Interface for Direct Collaboration Between Brains // Human–Computer Interaction, May 22, 2019 // arxiv.org/­abs/­1809.08632.

56. Ramchurn R. Now Playing: A Movie You Control with Your Mind // MIT Technology Review, May 25, 2018 // technologyreview.com/­s/­611189/­now-playing-a-movie-you-control-with-your-mind/­.

Ãëàâà 8. Áóäóùåå îáðàçîâàíèÿ

1. Ïîëíûé îò÷åò Ìèíèñòåðñòâà îáðàçîâàíèÿ ÑØÀ Our Future, Our Teachers: The Obama Administration’s Plan for Teacher Education Reform and Improvement ìîæíî ïðî÷åñòü çäåñü: ed.gov/­sites/­default/­files/­our-future-our-teachers.pdf.

2. UNESCO. The World Needs Almost 69 Million New Teachers to Reach the 2030 Education Goals // UNESCO Institute for Statistics. October 2016. No. 39 // uis.unesco.org/­sites/­default/­files/­documents/­fs39-the-world-needs-almost-69-million-new-teachers-to-reach-the-2030-education-goals-2016-en.pdf.

3. Ýòè âîïðîñû ïðåêðàñíî îñâåùàåò â ñâîåé ðàáîòå Êåí Ðîáèíñîí: Robinson K. Out of Our Minds. Capstone, 2011.

4. Ïîëíûé òåêñò âûñòóïëåíèÿ çàììèíèñòðà îáðàçîâàíèÿ ÑØÀ Òîíè Ìèëëåðà â èþëå 2011 ã. ìîæíî ïðî÷åñòü çäåñü: ed.gov/­news/­speeches/­partnering-education-reform.

5. Ïîëíûé òåêñò äîêëàäà The Silent Epidemic Perspectives of High School Dropouts («Áåçìîëâíàÿ ýïèäåìèÿ: ÷òî îæèäàåò ñòàðøåêëàññíèêîâ, áðîñèâøèõ øêîëó»): docs.gatesfoundation.org/­documents/­thesilentepidemic3-06final.pdf.

6. Talbot D. Given Tablets but No Teachers, Ethiopian Children Teach Themselves // MIT Technology Review, October 29, 2012 // technologyreview.com/­s/­506466/­given-tablets-but-no-teachers-ethiopian-children-teach-themselves/­.

9. Ïîëíûé òåêñò TED-ëåêöèè Ñóãàòû Ìèòðû Kids Can Teach Themselves («Äåòè ìîãóò ñàìîîáó÷àòüñÿ») ñì.: ted.com/­talks/­sugata_­mitra_­shows_­how_­kids_­teach_­themselves?­language=en.

10. Ïîëíûé òåêñò TED-ëåêöèè Ñóãàòû Ìèòðû Kids Can Teach Themselves («Äåòè ìîãóò ñàìîîáó÷àòüñÿ») ñì.: ted.com/­talks/­sugata_­mitra_­shows_­how_­kids_­teach_­themselves?­language=en.

12. Ïî äàííûì èññëåäîâàòåëüñêîé è êîíñàëòèíãîâîé êîìïàíèè â îáëàñòè ÈÒ Gartner, â 2017 ã. áûëî ïðîäàíî áîëåå 1,5 ìëðä ñìàðòôîíîâ. Èç íèõ 1,32 ìëðä ðàáîòàëè íà ÎÑ Android. Èñòî÷íèê: Gartner Newsroom, Press Releases. Gartner Says Worldwide Sales of Smartphones Recorded First Ever Decline During the Fourth Quarter of 2017 // gartner.com/­en/­newsroom/­press-releases/­2018-02-22-gartner-says-worldwide-sales-of-smartphones-recorded-first-ever-decline-during-the-fourth-quarter-of-2017.

13. Áåñåäà àâòîðà ñ Ôèëèïïîì Ðîñäåéëîì, 2018. Âèäåîòóð ìîæíî ïîñìîòðåòü çäåñü: youtube.com/­watch?v=zb2NUs0IDm4ut.

14. Bailey F., Pransky K. Implications and applications of the latest brain research for learners and teachers. Webinar, 2015, July 16 // Association for Supervision and Curriculum Development Webinar Series // ascd.org/­professional-development/­webinars/­implications-and-applications-of-brain-research-webinar.aspx.

15. Áèîãðàôè÷åñêóþ ñïðàâêó ñì. çäåñü: vhil.stanford.edu/­faculty-and-staff/­.

16. Herrera F. Building Long-Term Empathy: A Large-Scale Comparison of Traditional and Virtual Reality Perspective-Taking // PLoS ONE, October 17, 2018. Vol. 13. No. 10 // vhil.stanford.edu/­mm/­2018/­11/­herrera-pone-building-long-term-empathy.pdf.

17. Áèîãðàôè÷åñêóþ ñïðàâêó ñì. çäåñü: ict.usc.edu/­profile/­albert-skip-rizzo/­.

18. Maples-Keller J. The Use of Virtual Reality Technology in the Treatment of Anxiety and Other Psychiatric Disorders // Harvard Review of Psychiatry, May-June 2017. Vol. 25. No. 3. Pp. 103–113 // ncbi.nlm.nih.gov/­pmc/­articles/­PMC5421394/­.

19. Ñòèâåíñîí Í. Àëìàçíûé âåê. Ì.: Fanzon, 2019.

20. Alba D. Sci-Fi Author Neal Stephenson Joins Mystery Startup as ‘Chief Futurist’ // Wired, December 16, 2014 // wired.com/­2014/­12/­neal-stephenson-magic-leap/­.

Ãëàâà 9. Áóäóùåå çäðàâîîõðàíåíèÿ

1. Áåñåäà àâòîðà ñ Ìàðòèíîé Ðîòáëàòò, 2018. Ïîäðîáíåå î Ìàðòèíå ñì.: Tucker N. Martine Rothblatt: She Founded Siriusxm, a Religion and a Biotech. For Starters // Washington Post, December 12, 2014 // washingtonpost.com/­lifestyle/­magazine/­martine-rothblatt-she-founded-siriusxm-a-religion-and-a-biotech-for-starters/­2014/­12/­11/­5a8a4866-71ab-11e4-ad12-373­4c4­61e­ab6_­story.html; Reed T. Martine Rothblatt’s Theory of Evolution // Puget Sound Business Journal, April 3, 2018 // bizjournals.com/­seattle/­bizwomen/­news/­latest-news/­2018/­04/­martine-rothblatts-theory-of-evolution.html.

2. Ñì.: unither.com/­.

3. Sorvino C. How CEO Martine Rothblatt Turns Moonshots into Earthshots // Forbes, June 20, 2018. Ñì. òàêæå: Tucker, Martine Rothblatt.

4.  2018 ã. â ÑØÀ áûëî ïåðåñàæåíî 2530 ëåãêèõ. Áîëåå ïîäðîáíûå ñâåäåíèÿ ïî òðàíñïëàíòàöèè îðãàíîâ ñì.: unos.org/­data/­transplant-trends/­.

7. Îïèñàíèå òåõíîëîãèè ïåðôóçèè ëåãêîãî ex vivo ñì.: Makdisis G. Ex Vivo Lung Perfusion Review of a Revolutionary Technology // Annals of Translational Medicine. 2017. Vol. 5. No. 17 // ncbi.nlm.nih.gov/­pmc/­articles/­PMC5599284/­. Ñì. òàêæå ïðåññ-ðåëèç, ãäå ñîîáùàåòñÿ, ÷òî FDA îäîáðèëà îäíó èç ðàçðàáîòàííûõ United Therapeutics ïðîöåäóð ïåðôóçèè ëåãêîãî ex vivo: biospace.com/­article/­releases/­united-therapeutics-announces-fda-approval-of-xps-and-steen-solution-used-to-perform-centralized-ex-vivo-lung-perfusion-services/­.

8. Ðîòáëàòò, Îïèñàíèå òåõíîëîãèè ïåðôóçèè ëåãêîãî ex vivo ñì.: Makdisis G. Ex Vivo Lung Perfusion Review of a Revolutionary Technology // Annals of Translational Medicine. 2017. Vol. 5. No. 17 // ncbi.nlm.nih.gov/­pmc/­articles/­PMC5599284/­. Ñì. òàêæå ïðåññ-ðåëèç, ãäå ñîîáùàåòñÿ, ÷òî FDA îäîáðèëà îäíó èç ðàçðàáîòàííûõ United Therapeutics ïðîöåäóð ïåðôóçèè ëåãêîãî ex vivo: biospace.com/­article/­releases/­united-therapeutics-announces-fda-approval-of-xps-and-steen-solution-used-to-perform-centralized-ex-vivo-lung-perfusion-services/­.

9. New York Times ïîìåñòèëà ïîäðîáíûé ìàòåðèàë î êñåíîòðàíñïëàíòàöèè, êîòîðûé ìîæíî ïðî÷åñòü çäåñü: Clynes T. 20 Americans Die Each Day Waiting for Organs. Can Pigs Save Them? // New York Times Magazine, November 11, 2018 // nytimes.com/­interactive/­2018/­11/­14/­magazine/­tech-design-xenotransplantation.html?emc=edit_­nn_­20181114&nl=morning-briefing&nlid=­821­538­132­018­1114&te=1&mtrref=­undefined&assetType=­PAYWALL. Ñì. òàêæå ñòàòüþ â æóðíàëå Nature: Reardon S. New Life for Pig Organs // Nature, November 12, 2015 // nature.com/­news/­polopoly_­fs/­1.18768!/­menu/­main/­topColumns/­topLeft­Column/­pdf/­527152a.pdf?­origin=­ppub.

10. Ðîòáëàòò, New York Times ïîìåñòèëà ïîäðîáíûé ìàòåðèàë î êñåíîòðàíñïëàíòàöèè, êîòîðûé ìîæíî ïðî÷åñòü çäåñü: Clynes T. 20 Americans Die Each Day Waiting for Organs. Can Pigs Save Them? // New York Times Magazine, November 11, 2018 // nytimes.com/­interactive/­2018/­11/­14/­magazine/­tech-design-xenotransplantation.html?emc=edit_­nn_­20181114&nl=morning-briefing&nlid=­821­538­132­018­1114&te=1&mtrref=­undefined&assetType=­PAYWALL. Ñì. òàêæå ñòàòüþ â æóðíàëå Nature: Reardon S. New Life for Pig Organs // Nature, November 12, 2015 // nature.com/­news/­polopoly_­fs/­1.18768!/­menu/­main/­topColumns/­topLeft­Column/­pdf/­527152a.pdf?­origin=­ppub.

11. Regalado A. Inside the Effort to Print Lungs and Breathe Life into Them with Stem Cells // MIT Technology Review, June 28, 2018 // technologyreview.com/­s/­611236/­inside-the-effort-to-print-lungs-and-breathe-life-into-them-with-stem-cells/­.

12. Ñì.: beta.team/­. Ñì. òàêæå: Adams E. Beta Technologies, a Vermont Air Taxi Start-Up, Might Be About to Change the Aviation World // Drive, January 11, 2019 // thedrive.com/­tech/­25914/­beta-technologies-a-vermont-e-vtol-air-taxi-start-up-might-be-about-to-change-the-aviation-world (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì).

13. Allen M. Unecessary Tests and Treatments // Scientific American, November 29, 2017 // scientificamerican.com/­article/­unnecessary-tests-and-treatment-explain-why-health-care-costs-so-much/­. Ñì. òàêæå: nap.edu/­read/­13444/­chapter/­1#xvii.

14. Òàáëèöà «Ðàçðàáîòêà íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ», ïîäãîòîâëåííàÿ Êàëèôîðíèéñêîé àññîöèàöèåé áèîìåäèöèíñêèõ èññëåäîâàíèé: studylib.net/­doc/­8182066/­fact-sheet-new-drug-development-process.

15. Òàáëèöà «Ðàçðàáîòêà íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ», ïîäãîòîâëåííàÿ Êàëèôîðíèéñêîé àññîöèàöèåé áèîìåäèöèíñêèõ èññëåäîâàíèé: studylib.net/­doc/­8182066/­fact-sheet-new-drug-development-process.

17. Ïîäðîáíûå äîêëàäû âûøåóïîìÿíóòûõ Centers for Medicare & Medicaid Services ñì.: cms.gov/­newsroom/­press-releases/­2016-2025-projections-national-health-expenditures-data-released.

18. Gurdus L. Tim Cook: Apple’s Greatest Contribution Will Be ‘About Health’ // CNBC, January 8, 2019 // cnbc.com/­2019/­01/­08/­tim-cook-teases-new-apple-services-tied-to-health-care.html.

19. Ñïåöèàëèñòû ïî áèçíåñ-àíàëèòèêå èç êîìïàíèè CB Insights ïðîäåëàëè îòëè÷íóþ ðàáîòó — äàëè îáùèé îáçîð ýêîñèñòåìû hi-tech-çäðàâîîõðàíåíèÿ â äâóõ äîêëàäàõ: cbinsights.com/­research/­top-tech-companies-healthcare-investments-acquisitions/­; cbinsights.com/­research/­google-amazon-apple-health-insurance/­.

20. Ñì.: ouraring.com (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì).

21. Exo Imaging íåäàâíî âûñêî÷èëà êàê ÷åðò èç òàáàêåðêè ñ ïðèâëå÷åííûì êàïèòàëîì 35 ìëí äîëë. Ïîëíûé òåêñò èõ ïðåññ-ðåëèçà ñì.: https:/­/­www.businesswire.com/­news/­home/­201­908­050­051­14/­en/­Exo-Imaging-Emerges-Stealth-Mode-35M-Series. Ñì. òàêæå: exo-imaging.com (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì).

22. Ìýðè Ëó Äæåïñåí ðàññêàçàëà î êîìïàíèè Openwater â ñâîåì TED-âûñòóïëåíèè, êîòîðîå ìîæíî ïîñìîòðåòü çäåñü: youtube.com/­watch?v=awADEuv5vWY. Ñì. òàêæå: openwater.cc/­about-us. (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì).

25. Ïðîãíîç ïðèâîäèòñÿ àãåíòñòâîì Zion Market Research Group â äîêëàäå, îçàãëàâëåííîì mHealth Market by Devices, by Stakeholder, by Service, by Therapeutics and by Applications: Global Industry Perspective, Comprehensive Analysis and Forecast, 2014–2022 // zionmarketresearch.com/­report/­mhealth-market.  ýòîì ïðåññ-ðåëèçå åñòü íåêîòîðûå ñâåäåíèÿ èç äîêëàäà: globenewswire.com/­news-release/­2017/­11/­15/­1193431/­0/­en/­mHealth-Market-Size-Projected-to-Reach-USD-102-43-Billion-by-2022-Zion-Market-Research.html.

26. Molteni M. The Chatbot Therapist Will See You Now // Wired, June 7, 2017 // wired.com/­2017/­06/­facebook-messenger-woebot-chatbot-therapist/­. Ñì. òàêæå: woebot.io.

28. Stein R. Routine DNA Sequencing May Be Helpful and Not as Scary as Feared // NPR, June 26, 2017 // npr.org/­sections/­health-shots/­2017/­06/­26/­534338576/­routine-dna-sequencing-may-be-helpful-and-not-as-scary-as-feared.

29. Vasey J. The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial // Annals of Internal Medicine. 2017. Vol. 67. No. 3. Pp. 159–169 // annals.org/­aim/­fullarticle/­2633848/­impact-whole-genome-sequencing-primary-care-outcomes-healthy-adult-patients.

30. Ïîäðîáíîñòè óñëîâèé è ôèíàíñèðîâàíèÿ ïðîåêòà All of Us ìîæíî íàéòè íà ñàéòå Íàöèîíàëüíûõ èíñòèòóòîâ çäðàâîîõðàíåíèÿ: allofus.nih.gov.

31. Q&A: George Church and Company on Genomic Sequencing, Blockchain, and Better Drugs // Science, February 8, 2018 // sciencemag.org/­news/­2018/­02/­q-george-church-and-company-genomic-sequencing-blockchain-and-better-drugs. Ïîäðîáíåå î êîìïàíèè Nebula Genomics ñì. íà åå ñàéòå: nebula.org.

32. Li Y. Genome-Edited Skin Epidermal Stem Cells Protect Mice from Cocaine — Seeking Behaviour and Cocaine Overdose // Nature Biomedical Engineering. 2019. Vol. 3. Pp. 105–113 // nature.com/­articles/­s41551-018-0293-z.

33. Amoasii L. Gene Editing Restores Dystrophin Expression in a Canine Model of Duchenne Muscular Dystrophy // Science. Vol. 362. No. 6410. Pp. 86–91 // science.sciencemag.org/­content/­362/­6410/­86.

34. Mullin E. FDA Approves Groundbreaking Gene Therapy for Cancer // MIT Technology Review, August 30, 2017 // technologyreview.com/­s/­608771/­the-fda-has-approved-the-first-gene-therapy-for-cancer/­.

35. Molteni M. Here’s the Plan to End Malaria with Crispr-Edited Mosquitos // Wired, September 24, 2018 // wired.com/­story/­heres-the-plan-to-end-malaria-with-crispr-edited-mosquitoes/­. Ñì. òàêæå ïåðâóþ æóðíàëüíóþ ñòàòüþ: Windbichler N. Targeting the X Chromosome During Spermatogenesis Induces Y Chromosome Transmission Ratio Distortion and Early Dominant Embryo Lethality in Anopheles gambiae // PLoS Genet. 2008. Vol. 4. No. 12 // ncbi.nlm.nih.gov/­pmc/­articles/­PMC2585807/­.

36. Reuell P. A Step Forward in DNA Base Editing // Harvard Gazette, October 25, 2017 // news.harvard.edu/­gazette/­story/­2017/­10/­a-step-forward-in-dna-base-editing/­.

37. Ben-Senior L. [Infographic] 10 Most Common Genetic Diseases // LabRoots, May 22, 2018 // labroots.com/­trending/­infographics/­8833/­10-common-genetic-diseases.

38. Bridenstine Says NASA Planning for Human Mars Missions in 2030s // Space News, July 16, 2019 // spacenews.com/­bridenstine-says-nasa-planning-for-human-mars-missions-in-2030s/­.

39. Summers R. Emergencies in Space // The Practice of Emergency Medicine/Concepts, 2005 // pdfs.semanticscholar.org/­a102/­d4e61620dd77f93639cf47492f7ca6f8c44f.pdf.

40. Âûñòóïëåíèå Èëîíà Ìàñêà íà êîíôåðåíöèè ISS R&D Conference 19 èþëÿ 2017 ã. ñì.: youtube.com/­watch?v=BqvBhhTtUm4 (ñ ïåðåâîäîì íà ðóññêèé ÿçûê: trshow.info/­watch/­ITE6mg7uvPI/­-lon-mask-na-ss-r-d-conference-2017-19-07-2017-na-russkom.html).

41. Brown A. Smooth Operator: Robot Could Transform Soft-Tissue Surgery // Alliance of Advanced Biomedical Engineering, August 14, 2017 // aabme.asme.org/­posts/­smooth-operator-robot-could-transform-soft-tissue-surgery.

42. Hall M. J. Ambulatory Surgery Data from Hospitals and Ambulatory Surgery Centers: United States, 2010 // Centers for Disease Control National Health Statistics Reports. February 28, 2017. No. 102 // cdc.gov/­nchs/­data/­nhsr/­nhsr102.pdf.

43. Frangou C. An Eye on Surgical Robots // General Surgery News, July 9, 2018.

44. Òåêñò ïåðâîíà÷àëüíîãî ïðåññ-ðåëèçà îá ó÷ðåæäåíèè ïàðòíåðñòâà ñì.: jnj.com/­media-center/­press-releases/­johnson-johnson-announces-formation-of-verb-surgical-inc-in-collaboration-with-verily. Áîëåå ïîëíóþ èíôîðìàöèþ ïî Verb Surgical ñì. òàêæå: verbsurgical.com.

45. Ñì.: bionautlabs.com (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì).

46. Zhavoronkov A. Artificial Intelligence for Drug Discovery, Biomarker Development, and Generation of Novel Chemistry // Molecular Pharmaceutics. 2018. Vol. 5. Pp. 4311‚ ai4313.

48. Àìåðèêàíñêèå Íàöèîíàëüíûå èíñòèòóòû çäðàâîîõðàíåíèÿ äåðæàò áèáëèîòåêó CAD-ôàéëîâ 3D-ïå÷àòíûõ ôóíêöèîíàëüíûõ ïðîòåçîâ, ñì. çäåñü: 3-Dprint.nih.gov/­collections/­prosthetics.

49. Park S. H. 3-D Printed Polymer Photodetectors // Advanced Materials. October 4, 2018. Vol. 30. No. 40 // onlinelibrary.wiley.com/­doi/­abs/­10.1002/­adma.201803980.

50. Îñíîâû ïîíÿòèÿ ñòâîëîâûõ êëåòîê ñì. çäåñü: stemcells.nih.gov/­info/­basics/­4.htm.

51. Áåñåäà àâòîðà ñ Ðîáåðòîì Õàðèðè, 2018.

52. Áåñåäà àâòîðà ñ Ðîáåðòîì Õàðèðè, 2018.

53. Íàöèîíàëüíûé èíñòèòóò ðàêà ÑØÀ (US National Cancer Institute) äîõîä÷èâî îïèñûâàåò ñóòü òåõíîëîãèè CAR-T-òåðàïèè çäåñü: cancer.gov/­about-cancer/­treatment/­research/­car-t-cells.

54. Rockoff J. The Million-Dollar Cancer Treatment: Who Will Pay? // Wall Street Journal, April 26, 2018 // wsj.com/­articles/­the-million-dollar-cancer-treatment-no-one-knows-how-to-pay-for-1524740401.

56. Ñì. ïîäãîòîâëåííîå FDA îïèñàíèå ïðîöåññà ðàçðàáîòêè íîâûõ ëåêàðñòâåííûõ ïðåïàðàòîâ: fda.gov/­patients/­drug-development-process/­step-1-discovery-and-development.

57. DiMasi J. Innovation in the Pharmaceutical Industry: New Estimates of R&D Costs // Journal of Health Economics. May 2016. Vol. 47. Pp. 20–33 // doi.org/­10.1016/­j.jhealeco.2016.01.012.

58. Áåñåäà àâòîðà ñ Àëåêñîì Æàâîðîíêîâûì, 2018. Ïîäðîáíåå î êîìïàíèè Insilico Medicine, ñì.: insilico.com (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì).

59. Áåñåäà àâòîðà ñ Àëåêñîì Æàâîðîíêîâûì, 2018. Ïîäðîáíåå î êîìïàíèè Insilico Medicine, ñì.: insilico.com (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì). Áîëåå ïîäðîáíûå ñâåäåíèÿ ìîæíî íàéòè â òåìàòè÷åñêîì âûïóñêå æóðíàëà Àìåðèêàíñêîãî õèìè÷åñêîãî îáùåñòâà (American Chemical Society) Molecular Pharmaceutics, ïî òåìå ïðèìåíåíèÿ ÈÈ äëÿ îòêðûòèÿ íîâûõ ëåêàðñòâ.

60. Zhavoronkov A. Deep Learning Enables Rapid Identification of Potent DDR1 Kinase Inhibitors // Nature Biotechnology. 2019. Vol. 37. Pp. 1038–1040 // nature.com/­articles/­s41587-019-0224-x (âåí÷óðíàÿ êîìïàíèÿ Ïèòåðà âûñòóïàåò èíâåñòîðîì).

61. Renneberg R. Biotechnology for Beginners. Academic Press, 2016. P. 281.

63. Îá AlphaFold ìîæíî ïðî÷åñòü â áëîãå DeepMind çäåñü: deepmind.com/­blog/­alphafold/­.

Ãëàâà 10. Ïåðñïåêòèâû äîëãîæèòåëüñòâà

1. Äîêòîð Ôðýíñèñ Êîëëèíç è Ïèòåð â 2018 ã. âûñòóïàëè íà îäíîì ìåðîïðèÿòèè, êîòîðîå ïðèíèìàë Cura Foundation — Ôîíä, èíèöèèðîâàâøèé äâèæåíèå çà âñåîáùåå çäîðîâüå â ìèðå. Áåñåäó î äîëãîæèòåëüñòâå è íðàâñòâåííîé ñòîðîíå ïðîäëåíèÿ æèçíè äî áåñêîíå÷íîñòè ñì. çäåñü: youtube.com/­watch?v=z6i0yTA4zRM. Ñâîè âïå÷àòëåíèÿ îò îáùåíèÿ ñ äîêòîðîì Êîëëèíçîì Ïèòåð îïèñàë â ñâîåé ñòàòüå: Diamandis P. The Morality of Immortality, 2018 // diamandis.com/­blog/­the-morality-of-immortality.

2. Lopez-Otin C. The Hallmarks of Aging // PMC, November 23, 2013. Ñì. òàêæå: The Future of Aging? The New Drugs & Tech Working to Extend Life & Wellness // CB Insights, ncbi.nlm.nih.gov/pmc/articles/PMC3836174/; CB Insights’ report on the future of aging // cbinsights.com/­research/­report/­future-aging-technology-startups/­.

3. Πðîëè è çíà÷åíèè C. elegans â èçó÷åíèè ãåíåòèêè ñì.: Giurumescu C. A. Cell Identification and Cell Lineage Analysis // Methods in Cell Biology, 2011 // doi.org/­10.1016/­B978-0-12-544172-8.00012-8.

4. C. elegans Sequencing Consortium. Genome Sequence of the Nematode C. Elegans: A Platform for Investigating Biology // Science, December 11, 1998 // ncbi.nlm.nih.gov/­pubmed/­9851916.

5. Cook S. J. Whole-Animal Connectomes of Both Caenorhabditis elegans Sexes // Nature, July 3, 2019 // nature.com/­articles/­s41586-019-1352-7.

6. Ïåðâóþ ñòàòüþ îá ýòîì ñì. çäåñü: Chen D. Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans // Cell Reports, December 26, 2013 // doi: 10.1016/­j.celrep.2013.11.018. Ñì. òàêæå: NIH director Dr. Francis Collins’s take on the study. Deciphering Secrets of Longevity, from Worms // NIH Director’s Blog, January 7, 2014. Ñì. ïåðâóþ ñòàòüþ îá ýòîì èññëåäîâàíèè çäåñü: directorsblog.nih.gov/­2014/­01/­07/­deciphering-secrets-of-longevity-from-worms/­.

7. Collins, Deciphering Secrets.

8. Sutphin G. L. Caenorhabditis elegans Orthologs of Human Genes Differentially Expressed with Age Are Enriched for Determinants of Longevity // Aging Cell, April 2017 // onlinelibrary.wiley.com/­doi/­full/­10.1111/­acel.12595.

9. Riley J., Roser M. Life Expectancy by World Region // Our World in Data, 2015 // ourworldindata.org/­life-expectancy.

10. Ðýé Êóðöâåéë â áåñåäå ñ àâòîðîì, 2018. Ñì. òàêæå áåñåäó Ðýÿ è Ïèòåðà, â êîòîðîé îíè îáñóæäàþò êîíöåïöèþ longevity escape velocity (ñêîðîñòè óáåãàíèÿ îò ñòàðåíèÿ): youtube.com/­watch?time_­continue=­2&v=­SaO­fLt­oaK­qw.

11. Peikoff K. Anti-Aging Pioneer Aubrey de Grey: ‘People in Middle Age Now Have a Fair Chance’ // Leapsmag, January 30, 2018 // leapsmag.com/­anti-aging-pioneer-aubrey-de-grey-people-middle-age-now-fair-chance/­.

12. Schwarz J. The Right Chemistry: Easter Island Might Just Hold the Key to Fighting Aging // Montreal Gazette, March 5, 2019.

13. Halford B. Rapamycin’s Secrets Unearthed // C&EN, July 18, 2016. Ñì. òàêæå: Gifford B. Does a Real Anti-Aging Pill Already Exist? // Bloomberg, July 12, 2015.

14. Serruys P. W. Rapamycin Eluting Stent: The Onset of a New Era in Interventional Cardiology // Heart, April 2002.

15. Morath C. Sirolimus in Renal Transplantation // Nephrology Dialysis Transplantation, September 2007.

16. Zaytseva Y. Y. mTOR Inhibitors in Cancer Therapy // Cancer Letters, June 2012 // doi.org/­10.1016/­j.canlet.2012.01.005.

17. Harrison D. E. Rapamycin Fed Late in Life Extends Lifespan in Genetically Heterogeneous Mice // Nature, July 8, 2019.

18. Mannick J. B. mTOR Inhibition Improves Immune Function in the Elderly // Science Translational Medicine, December 2014.

19. Barzilai N. Metformin as a Tool to Target Aging // Cell Metabolism, June 14, 2016. Vol. 23. No. 6. Pp. 1060–1065 // ncbi.nlm.nih.gov/­pmc/­articles/­PMC5943638/­.

21. van Deursen J. M. Senolytic Therapies for Healthy Longevity // Science, May 2019. Vol. 364. No. 6441. Pp. 636–637.

22. Áåñåäà àâòîðà ñ Îñìàíîì Êèáàðîì, 2018. Ñì. òàêæå: samumed.com/­default.aspx.

23. Gormley B. Drugmaker Samumed Closes $438 Million Round at $12 Billion Pre-Money Valuation // Wall Street Journal Pro, August 6, 2018 // wsj.com/­articles/­drugmaker-samumed-closes-438-million-round-at-12-billion-pre-money-valuation-1533602014.

24. Khan M. Wnt Signaling in Stem Cells and Cancer Stem Cells: A Tale of Two Coactivators // Science Direct, January 2018. Îáçîð ñì.: sciencedirect.com/­science/­article/­pii/­S1877117317301850.

25. Áåñåäà àâòîðà ñ Îñìàíîì Êèáàðîì.

27. Park J. Various Types of Arthritis in the United States: Prevalence and Age-Related Trends from 1999 to 2014 // American Journal of Public Health, October 5, 2017. Õîòÿ äàííîå èññëåäîâàíèå çàòðîíóëî òîëüêî ÑØÀ, âåäóùèé èññëåäîâàòåëü äîêòîð Ïàðê ïîçæå ýêñòðàïîëèðîâàë ðåçóëüòàòû çäåñü: fau.edu/­newsdesk/­articles/­arthritis-trends.php.

28. Yazici Y. A Novel Wnt Pathway Inhibitor, SM04690, for the Treatment of Moderate to Severe Osteoarthritis of the Knee: Results of a 24-Week, Randomized, Controlled, Phase 1 Study // Osteoarthritis and Cartilage, October 2017 // ncbi.nlm.nih.gov/­pubmed/­28711582.

29. Áåñåäà àâòîðà ñ Îñìàíîì Êèáàðîì.

30. Samumed LLC. A Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SM04755 Following Topical Administration to Healthy Subjects // U.S. National Library of Medicine, July 25, 2017. Ñì. òàêæå: Samumed LLC. A Repeat Insult Patch Test (RIPT) Study Evaluating the Sensitization Potential of Topical SM04755 Solution in Healthy Volunteers // U.S. National Library of Medicine, April 18, 2018 // clinicaltrials.gov/­ct2/­show/­NCT03229291?term=samumed&recrs=e&phase=0&rank=1. Ñì. òàêæå: clinicaltrials.gov/­ct2/­show/­NCT03502434?term=samumed&recrs=e&phase=0&rank=2.

31. Samumed LLC. A Study Utilizing Patient-Reported and Radiographic Outcomes and Evaluating the Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Moderately to Severely Symptomatic Knee Osteoarthritis (STRIDES-X-ray) // U.S. National Library of Medicine, April 26, 2019 // clinicaltrials.gov/­ct2/­show/­NCT03928184?term=samumed&phase=2&rank=1.

32. Áåñåäà àâòîðà ñ Îñìàíîì Êèáàðîì.

33. Wright D. E. Physiological Migration of Hematopoietic Stem and Progenitor Cells // Science, November 2001 // ncbi.nlm.nih.gov/­pubmed/­11729320.

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